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Under physiological conditions, the TK bond exhibits extremely high stability, thereby effectively reducing the leakage of the drug in non-target tissues
Moreover, treatment with tert-butylhydroquinone (tBHQ) or PMA has been shown to promote PKC-mediated phosphorylation of NRF2 in HepG2 cells, leading to enhanced nuclear localization of NRF2
[PubMed: 19501077] 258
[DOI] [PMC free article] [PubMed] [Google Scholar] 194.Banerjee S., Mukherjee S., Mitra S., Singhal P
doi: 10.1242/dev.068858
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