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Other significant factors include genetic variations, nutritional deficiencies of cofactors (copper, zinc, manganese), overwhelming oxidative stress, and inflammatory conditions that alter SOD expression or activity

The three consecutive proline residues create a rigid structural element

Furthermore, studies of IGF-2 gene in transitional cell carcinoma of the bladder and MGMT gene in gastric cancer showed that patients with CT or TT MTHFR genotypes had reduced methylation of IGF-2 or MGMT compared those with CC genotype 36,37

Glucosinolates/isothiocyanates are among the most potent known activators of the Nrf2 antioxidant response element pathway the master regulator of the body's endogenous antioxidant gene expression, including glutathione synthesis, SOD, and catalase.*

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