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One of the most significant changes was increased DNA methylation in an intron of the disks large homolog 4 ( Dlg4 ) gene

Genetics 224 , iyad031 (2023)

Furthermore, activated JNK translocates the mitochondria, and recruits cytoplasmic Bax, which triggers the opening of MPTP, thereby leading to the loss of membrane potential and the depletion of ATP

Effect of the onecarbon unit cycle on overall dna methylation in children with down's syndrome

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we explored these results full-length, and reviewed their list of references as well as PubMed related articles to completely cover all published molecular pathophysiological knowledge