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This chemical library covered 25 pathways in 7 different functional classes in Zmpste24 / MEFs a classic progeroid cell model that shows early cell senescence in vitro [22,23,24] (Fig

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Emerging evidence indicates that reactivation of oncogenic signaling pathways is frequently accompanied by parallel reprogramming of metabolic networks, forming a coordinated dual-track mechanism of resistance driven by signaling-metabolism crosstalk [75]

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27 Interestingly, Fer-1 and an iron chelator were also effective in preventing glutamate-induced cell death in an organotypic hippocampal slice culture model, suggesting that neuronal cell death in this model resembles erastin-induced cell death in cancer cells

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