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For instance, in preclinical models, long-term ketamine exposure increases the expression of GABA receptor subunits in the prefrontal cortex while simultaneously reducing glutamate receptor subunits, impairing synaptic signaling and cognitive function ( Ketamine also downregulates brain-derived neurotrophic factor, particularly in the hippocampus, exacerbating deficits in synaptic plasticity and cognitive functions

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Beyond the immediate onset, others describe a delayed or intermittent pattern

MS, mass spectrometry

Upon opening, it can last up to 40 days with refrigeration

Sterile Water for Injection (SWFI) or Bacteriostatic Water (BAC) are standard for accurate peptide dissolution