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Reported biochemical potency against human NNMT is in the low-micromolar range with cellular EC values in the low-micromolar range for suppression of 1-MNA and lipogenesis, with selectivity over related methyltransferases and NAD-salvage enzymes [1,6,7]
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Therefore, numbness and pain in the extremities from vitamin B12 deficiency can be mistaken for peripheral neuropathy in people with diabetes
Of the psychotherapy modalities, cognitive behavioral therapy has the greatest evidence for efficacy
de la Harpe KM, Kondiah PPD, Choonara YE, Marimuthu T, du Toit LC, Pillay V
