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Intervention Strategies: Anti-VEGF neutralizing antibodies (e.g., bevacizumab/B20) or anti-angiogenic tyrosine kinase inhibitors (e.g., axitinib), by blocking VEGF signaling, not only reduce pathological angiogenesis, edema, and hemorrhage but also decrease peripheral nerve density mediated by the interaction of VEGF with neuropilin (NRP), thereby alleviating pain

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Other disorders related to vascular obstruction, particularly stroke and retinopathy leading to loss of visual acuity and even blindness, can take a devastating toll

Funding Statement The authors are supported by grants from the National Institute of Health (NIH/NCCIH)-(5R33AT010637-01A1 and 3R33 AT010637-02S1) and the Malcolm Feist Endowed Chair in Diabetes

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