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In addition, HO-1 expression may also affect inflammatory mediators at a systemic level, as HO-1 null mice have been reported to exhibit greater plasma levels of monocyte chemotactic protein (MCP)-1 protein and increased levels of MCP-1 mRNA in circulating leukocytes as compared with wild-type mice (Pittock et al., 2005)

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Additionally, AHK-Cu helps minimize muscle contractions, reducing the appearance of fine lines and wrinkles for smoother, more youthful-looking skin

It can push stem or progenitor cells towards repair phenotypes and it advances regeneration-specific cell cycle genes

This crucial phase of the malady, in analogy with other viral infections and to a widely accepted pharmacological praxis, should be timely treated either with etiotropic drugs (which in COVID-19 case are still lacking) as well as with host-directed agents to manage/prevent the symptoms (Sestili and Stocchi, 2020)