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In the pre-experiments, we also used liquid chromatographymass spectrometry (LC-MS) to detect this peptide in mice blood at (83.5810.16) ng/ml in 1 hour after the mice were gavaged PGPIPN at 250g/kg body weight (data not shown)
Similarly, the drug should not be administered to patients with confirmed gastroparesis
The tissues were counterstained with DAPI (4,6-diamidino-2-phenylindole) for 10 min at room temperature to label the nuclei and then mounted on slides with anti-fade medium (ProLong Gold, Thermo Fisher Scientific Inc., Rockford, IL)
The extensive preclinical research foundation, favorable preclinical safety profile, and preliminary human experience suggest BPC-157 warrants continued investigation as a potential therapeutic agent for tissue repair and regeneration
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