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Lactate, the product of anaerobic glycolysis generated from pyruvate, appears to positively modulate TGF- signaling (Figure 2

In DMD-affected muscles, a decrease in VEGF expression was observed in our studies [34,35,36, 56] and an increase in its level was proposed as a strategy that could exert a beneficial effect on the pathology of DMD (reviewed in: [50])

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