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Kibble J.D

By activating the inflammatory pathways, TMAO promotes cardiac fibrosis, heart weight gain and cardiac remodeling

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L-carnitine may markedly lower blood pressure, have a positive effect on lipid profile and reduce the risk of heart attacks and death from cardiovascular incidents in people with cardiovascular disease

[DOI] [PMC free article] [PubMed] [Google Scholar] Lim PS, Wei YH, Yu YL, Kho B

Moreover, dietary supplementation with TMAO significantly decreased the expression of both enteral cholesterol transporters Niemann-Pick C1-like1 (Npc1L1), which transports cholesterol into enterocytes from the intestinal lumen, and ABCG5/8, which transports cholesterol out of enterocytes into the gut lumen (Jia et al., 2011