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Inverse Association Between Serum Vitamin B12 Concentration and Obesity Among Adults in the United States Obesity in children and adolescents was associated with an increased risk of low vitamin B(12) concentration

J.SandhuK.PetersonV.DinanT

Sci Rep 11 , 914 (2021)

Transitioning from these cellular findings to the robust identification of these circulating oxidized byproducts (such as 4-HNE, specific epoxy-derivatives, or altered ceramide ratios) in the bloodstream will solve two problems at once: providing a reliable, non-invasive tool to monitor FRDA progression and offering definitive proof of target engagement when testing new anti-ferroptotic drugs