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The biopsy showed a biphasic tumor with tubular or alveolar pattern with large melanin-containing cells with abundant cytoplasm and pale nuclei suggestive of MNTI

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The synthesis of the LDL receptor itself is regulated by feedback inhibition as intracellular levels of cholesterol increase

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However, cells are known to possess inherently poor antioxidant capacity (Lenzen et al., 1996), and this coupled with the lower levels of plasmalogens may result in enhanced susceptibility of cells to metabolic stress and ROS contributing to the autoimmune response