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These can include a small bruise at the injection site, slight pain, or a mild headache

Based on these results, we propose that inhibition of RNR (or upstream enzymes) leads to accumulation of GSH which can be re-purposed for use by GPX4 to prolong the inhibition of ferroptosis under conditions where new GSH synthesis is otherwise impossible (Fig 6)

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62 In these experiments, APAP caused severe liver injury with no significant LPO, but pretreatment with ferrous iron triggered extensive LPO and aggravated the injury (Fig

& Bozzola, J

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