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In addition, thiamine is known to be involved in the uptake of serotonin and GABA, which, when deficient, leads to cellular abnormalities that affect cerebellar, hypothalamic, and hippocampal activity

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However, there is considerable variability in doses and extract preparation, including oil-based formulations, methanol extracts and advanced nanoformulations, which might affect bioavailability and clinical efficacy

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In addition, excessive androgen receptor activation alters transcriptional regulation of genes involved in glucose and lipid metabolism, thereby promoting hepatic steatosis and insulin resistance (72)