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Heterogeneous cellular distribution of glutamate dehydrogenase in brain and in non-neural tissues

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The strategic implications for drug discovery, personalized therapy, and regulatory science are profoundly ushering in a new era where mRNA can be engineered not just to instruct cells, but to therapeutically reprogram them across a multitude of tissues and disease states

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In K15-Igf1r conditional knockout mice, loss of IGF-1R in follicular stem cells resulted in a decreased number of dermal papilla cells, abnormal follicular morphology, and reduced expression of BMP-4, a key regulator of folliculogenesis [58]

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