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Negative findings: A 3-month study in Iran among 48 adults (average age 57) with uncontrolled type 2 diabetes despite use of antidiabetes drugs showed that milk thistle seed extract (Livergol) standardized to 140 mg of silymarin per capsule (total daily dose 420 mg), combined with a controlled diet, did not significantly improve fasting blood sugar, HbA1c, cholesterol levels, weight, or BMI compared to diet alone (Ferdowsi, Phytother Res, 2024) [22]

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