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Moreover, it plays an important role in the development of many metabolic diseases, such as hypertension, diabetes, polycystic ovary syndrome (8), and osteoarthritis (9)

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The prevalence of cramps among individuals with chronic liver disease spans from 22 to 88%, mirroring the incidence observed in other chronic conditions such as type 1 diabetes mellitus (2434%), type 2 diabetes mellitus (4578%), and chronic kidney disease (5667%), yet markedly exceeding that of the general populace