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Angiogenesis cuts both ways: The pro-angiogenic, pro-migration mechanisms that make these peptides interesting for repair are the same processes that are undesirable in the presence of malignancy an unresolved theoretical concern and a genuine reason for caution

Note that some supplements fall into more than one category

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Elevated NAD+ levels activate sirtuins, particularly SIRT1, which are NAD+-dependent deacetylases that regulate numerous metabolic processes including fat oxidation, glucose metabolism, mitochondrial biogenesis, and cellular stress responses

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