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10.3390/antiox11050886 138

The route and dosage of supplementation depend on the severity of deficiency, presence of neurological symptoms, and underlying cause of the deficiency

Non-genetic animal models of ASD Environmental animal models are induced by prenatal exposure of pregnant animals to certain chemical compounds, infections, or inflammations

doi: 10.1152/physrev.00045.2009 41 OHaraAMShanahanF

Unlike the physical topdown strategy, which is based on chemical reactions, the bottomup approach creates atoms or molecules through a variety of chemical reactions

Advanced experimental models, including patient-derived intestinal organoids, high-resolution copper imaging techniques, and detailed dissection of copper-mitochondriaautophagy interactions, will be required before intestine-targeted therapeutic strategies can be rationally integrated into WD management