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10.1146/annurev-pathol-012513-104706 61

The liver is a key organ for endogenous carnitine synthesis and metabolism, and carnitine homeostasis in the liver has a major effect on carnitine levels in other tissues throughout the body [213, 214]

Specifically, LDHB depletion impairs GSH synthesis and leads to hypersensitivity of KRAS -mutant cancer cells to ferroptosis inducers, which is causally linked to increased glutaminolysis and mitochondrial ROS

An expansion of this study with a larger patient sample would help to understand if the different Grxs isoforms could characterize specific cancer cell subpopulations

Aging (Albany NY) 2018;10:1933

Abst.# H2-794a: "HAART Treatment Interruption following Adoptive Transfer of Zinc Finger Nuclease (ZFN) Modified Autologous CD4 T-cells (SB-728-T) to HIV-infected Subjects Demonstrates Durable Engraftment and Suppression of Viral Load." Late-Breaker Poster Session: Antiretroviral Therapy of HIV-1 Infection, 11:15 a.m