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Other substances, such as limonene, honokiol [141], Nrf2, carnosic acid, 1-(2-cyano-3,12,28-trioxolan-1,9(11)-died-28-yl)-1H-imidazole [142], and fisetin [143], help attenuate MGO accumulation by enhancing its detoxification

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The completion of GSH synthesis is catalyzed by glutathione synthetase (GS), in a reaction in which -glutamyl-cysteine is covalently linked to glycine ( Figure 1 )

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