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When the rate of ROS generation exceeds the clearance capacity of the body, there is an excessive accumulation of ROS, which react with Fe 2+ to induce lipid peroxidation, thereby initiating ferroptosis

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Epidiolex (cannabidiol) primer: Frequently asked questions for patients and caregivers

It is caused by severe mutations in genes encoding proteins involved in transcription-coupled nucleotide excision repair as well as in several other DNA repair processes