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These results indicate that APR-246 induces p53-independent effects in these cells and that these off-target effects prevent us from detecting any mutant-specific effects even at low doses

Chromatin remodelers such as CHD8 and ARID1B, along with histone demethylases KDM5C and KDM2B, suppress WNT by either inhibiting -catenin and regulating the expression of other WNT pathway genes [110,137,138,139]

Rodriguez et al

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