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Published rodent pharmacokinetic data report a plasma half-life consistent with once- or twice-daily oral administration for sustained NNMT inhibition

Over time, maintenance doses are scheduled at longer intervals

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(Source 1) Vitamin C supplementation also increases Bifidobacteria , a genus of beneficial bacteria in the gut, and positively modulates the microbiome

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Therefore, the FDA recommends that patients with ventricular dysfunction or heart failure should only prescribe this medication in cases of life-threatening fungal infections, not as a treatment for onychomycosis