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Metabolism: clinical and experimental , 46 (1), 8996

26 Over 100 gene loci, including those associated with presynaptic vesicle trafficking (PCLO), dopaminergic neurotransmission (a primary target of antipsychotics), glutamate ionotropic receptor kainate type subunit 5 (GRIK5), and metabotropic glutamate receptor 5 (GRM5), and neuronal calcium signaling such as calcium voltage-gated channel subunit alpha1 E (CACNA1E) and calcium voltage-gated channel auxiliary subunit alpha2 delta1 (CACNA2D1), are found to be associated with an increased risk of MDD by genome-wide association studies

Long SL, Gahan CGM, Joyce SA

A role in tumor development in patients with T2DM is also being investigated but further studies are required to fully understand the functions of GLP-1R and its agonists

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Conclusion Research on iron-lowering strategies in AD has been limited, likely due to the predominant focus on amyloid-lowering treatments, which have generally yielded unfavorable results (137,138)