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For researchers designing combination protocols, this approach makes mechanistic sense but requires dose-optimization work to avoid redundant effects or unexpected interactions
Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial
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In addition to affecting reward pathways, DYNKOR signaling also modulates cortico-striatal glutamatergic transmission and local inhibitory processes, thereby influencing higher cognitive functions [26,27]
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