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The relationship between MS and mitochondrial function is discussed, with a focus on disease-modifying therapies (DMTs)

They can be intense and painful, involving the contraction of a muscle or group of muscles

It causes joint hypermobility (joints that move too much!) which can result in joint dysfunction and pain

Discussion We have explored a simple and convergent self-assembled nano-prodrug containing an ALDH-activatable PS and differentiation agents ATRA for CSC-associated tumor treatment

While these molecular events can occur, evidence suggests that defects in proximal insulin signalling are not the major determinant of insulin resistance

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