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Clinical symptoms result from binding of IgM to red cells in vascular beds where the temperature may fall below 30C, such as in exposed fingers, toes, and ears

doi: 10.3389/fphar.2020.00730

Mold and mycotoxin testing may also be important for some patients

doi: 10.1016/j.ejim.2007.04.016 343

J Gen Virol 99(12):16581670 Kerur N et al (2013) TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy

Furthermore, CuSAE possesses peroxidase (POD)- and glutathione oxidase (GSHOx)-mimicking activities, which catalyze cascade reactions by using H 2 O 2 , the product of GOx catalysis, as a substrate, to generate OH radical and deplete cellular GSH