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The humanised anti-HGF antagonistic antibody ficlatuzumab did not yield clinical benefits as a monotherapy, but resulted in a 19% ORR in patients with HNSCC when combined with cetuximab [399]

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Oxidative Stress One of the principal contributors to oxidative stress in PD is mitochondrial dysfunction, particularly through ROSmediated damage
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Evaluation of thiol disulfide balance in adolescents with vitamin B12 deficiency