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Additionally, while the study did not distinguish among the types of claims challenged (e.g., method of treatment claims, formulation claims, compound claims), additional insight may be gleaned from such analysis, including which types of claims are more frequently challenged and cancelled.

Additionally, CAFs are capable of breaking down the ECM through the release of matrix metalloproteinases (MMPs) and the creation of novel matrix proteins involved in tumor penetration and angiogenesis [51,52,53]

Int J Mol Sci 26:2691

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