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Understanding these principles will allow clinicians to help their patients decide on the best approach to LDL-C lowering

But for people with L-carnitine deficiency, this is a serious medical condition

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When insulin signaling is impaired: Hepatic lipase activity increases, accelerating the breakdown of triglyceride-rich LDL into sdLDL Triglyceride levels rise due to increased hepatic VLDL production The ratio of triglycerides to HDL cholesterol increasesa key indicator of insulin resistance Clearance of sdLDL is reduced, prolonging its circulation time These changes collectively shift LDL particle distribution toward the more atherogenic small-dense phenotype