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Simple linear correlations were performed to reveal the associations between the variables

Abbreviations 5-HT: 5-hydroxytryptamine Ach: Acetylcholine AD: Alzheimers disease Ascl1: Achate-schute complex homolog-like 1 BBB: Blood-brain barrier BDNF: Brain-derived neurotrophic factor CNTF: Ciliary neurotrophic factor CREB: Cyclic AMP response element-binding protein CXCR4: CXC chemokine receptor 4 DKK3: Dickkopf 3 ER: Estrogen receptors GABA: Gamma-aminobutyric acid GDNF: Glial-derived nerve factor GLP-1: Glucagon-like peptide-1 ICV: Intracerebroventricular IL: Interleukin LPS: Lipopolysaccharide mGluRs: Metabotropic glutamate receptors MSCs: Mesenchymal stem cells NeuroD1: Neurogenic differentiation 1 NGF: Nerve growth factor NSAIDs: Non-steroidal anti-inflammatory drugs NSCs: Neural stem cells OB: Olfactory bulb Pax6: Paired box gene 6 PD: Parkinsons diseases PUFA: Poly-unsaturated fatty acids RBPJ: Recombination signal binding protein for immunoglobulin kappa J REST: RE1 silencing transcription factor RMS: Rostral migratory stream SGZ: Subgranular zone Sox2: SRY-related high-mobility-group box 2 SVZ: Subventricular Zone Tbr2: T-box brain gene 2 TFs: Transcription factors TGF- : Transforming growth factor- TLX: Orphan nuclear hormone receptor tailless TNFs: Tumor necrosis factors Trk: Tropomyosin-related kinase VEGF: Vascular endothelial growth factor References Eriksson PS, Perfilieva E, Bjork-Eriksson T, Alborn A-M, Nordborg C, Peterson DA, Gage FH

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Specific mechanisms may involve oxidative damage caused by excessive ROS production, and the persistent accumulation of such damage can lead to further cellular and organismal dysfunction, ultimately inducing various diseases [34]

10.1016/j.neuropharm.2012.04.010 158 LiechtiM

Chen H.W., et al