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On the other hand, gastrointestinal commensal bacteria, such as Bacteroides, Lactobacillus, and Bifidobacterium, can facilitate the development of Treg cells and, by this, increase the osteoblast activity (162)

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60 minutes pre-test Result:Increased the inhibition rate of cold allodynia by 28% at 0.1 mg/kg, 37% at 0.3 mg/kg, 50% at 1 mg/kg, 39% at 3 mg/kg, and 58% at 10 mg/kg compared to vehicle