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TFAM is almost exclusively present in a DNA-bound form (Takamatsu et al., 2002), and degradation of TFAM proteins by mitochondrial matrix proteases directly affects mtDNA copy number (Matsushima et al., 2010)

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Neroni B, Evangelisti M, Radocchia G, et al

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Association of hyperhomocysteinemia and chronic kidney disease in the general population: a systematic review and meta-analysis

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