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418 The Martin group developed a yeast strain that can produce the key THIQ intermediate 199 at 4.6 g/L

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doi: 10.1016/j.bbadis.2013.05.028 275 SteinerJLLangCH

This remains an area of investigational interest rather than documented clinical application

Ibarra-Costilla E, Cerda-Flores RM, Davila-Rodriguez MI, Samayo-Reyes A, Calzado-Flores C, Cortes-Gutierrez EI

A study looking at age-related differences in the gut microbiota composition among young (average 31-years old), elderly (average 72-years old), and centenarians humans (average 100- years old) demonstrated that the composition and diversity of the gut microbiota do not differ between young adults and elderly groups