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A blood transcriptome-based analysis of disease progression, immune regulation, and symptoms in coronavirus-infected patients

The pathway is divided into two main phases: an irreversible oxidative phase and a reversible non-oxidative phase

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Under oxidative stress, however, ROS accumulation induces intestinal cellular DNA damage and mitochondrial dysfunction, impairing goblet cell viability through apoptotic pathway activation

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Co-crystal structures of GSTO1 bound to inhibitors showed a covalent association with the active site cysteine (C32) with additional hydrophilic and hydrophobic interactions in the H-site
