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Description
Initially developed in the 1960s as a mucolytic agent (1), NAC was later identified as an effective antidote for acetaminophen toxicity by detoxifying N-acetyl-p-benzoquinone imine (NAPQI) (2) (Figure 1)
[DOI] [PMC free article] [PubMed] [Google Scholar] 120.Shih A.J., Adelson R.P., Vashistha H., Khalili H., Nayyar A., Puran R., Herrera R., Chatterjee P.K., Lee A.T., Truskinovsky A.M., et al
A randomized, double-blind, split-face study of topical silymarin vs 2% hydroquinone cream in melasmas
Keywords: bloodbrain barrier, brain endothelial cell, central nervous system disease, efflux transporter, nutraceutical, plant-derived compound, protection, signal transduction, solute carrier 1
If it lasts more than four weeks , its considered chronic
Desforges J-P, Sonne C, Dietz R, Levin M
