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Importantly, ischemic injury during time points coincident with low Per1 expression were more susceptible to apoptosis compared to high Per1 expression ( tPA and Circadian Rhythms, and Factors Involved in Hemorrhagic Transformation Blood-brain barrier dysfunction is a well-characterized occurrence post ischemia

J Pharm Sci 93:15371544 [DOI] [PubMed] [Google Scholar] Ebens A, Brose K, Leonardo ED, Hanson MG, Jr, Bladt F, Birchmeier C, Barres BA, Tessier-Lavigne M

When this happens it brings blood, oxygen and nutrients right to the injured area