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While the factors underlying brain health and longevity discussed below are not exhaustive, they represent what appear to be the most quantifiable and targetable factors underlying neurodegenerative processes along the MCI-ADRD continuum

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Our experiments further confirmed that the inhibition of AMPK could offset the protective effects of SIRT1 overexpression, indicating that AMPK mediates the protective role of SIRT1 against oxidative stress and mitochondrial dysfunction in hair cells (Fig

Role of ferroptosis in PD Ferroptosis is regulated by multiple interconnected pathways, including the GPX4/GSH system, iron and lipid metabolism, the NRF2 signaling pathway and mitochondrial function, in PD (Fig