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Rapid and random turnover of mitochondrial DNA in rat hepatocytes of primary culture

However, translating the promising in vitro and animal model findings of natural radioprotectors into clinically viable therapeutics remains a significant challenge

10.1002/hep.1840190630 [DOI] [PubMed] [Google Scholar] Liu M

Rapamycins efficacy is further limited due to its metabolism via cytochrome P450 3A4 (Cyp3A4), which is induced by rifampin, complicating its use alongside standard TB treatments

This increase in cytokine production further increases oxidative stress which in turn affects mitochondrial functioning and disrupts the production of ATP

Hepatic mitochondrial and cytosolic glutathione content and the subcellular distribution of GSH-S-transferases