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A recent study reported that an engineered biohybrid of DH5 Escherichia coli with hypoxia-inducible lactate oxidase and iron-doped zeolitic imidazolate framework-8 nanoparticles enables targeted lactate depletion, immune activation and ferroptosis, significantly inhibiting tumor growth and metastasis (178)

doi:10.1007/s00213-020-05629-2 84 Nery, F

This often correlates with reduced caloric intake as appetite suppression takes effect
Mititelu RR, Albu CV, Bacanoiu MV, Padureanu V, Padureanu R, Olaru G, Buga AM, Balasoiu M (2021) Homocysteine as a Predictor Tool in Multiple Sclerosis

As summarised in Table 1, iron-based platforms primarily modulate labile iron pools and chemodynamic Fenton activity
