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IGF-1 contributes to lung re-epithelialization, acting as an anti-apoptotic factor, and stimulates the in vitro synthesis of collagen by fibroblasts, thus leading to the production of extracellular matrix [83, 90, 91]

J Vasc Res 2007

Long-term use may also affect organ function, nutrient balance, and hormone regulation, and could lead to drug-to-drug interactions

Clinical trials using sermorelin or similar GHRH analogues report mean fat loss of 24% of total body weight over 1216 weeks, which translates to roughly 23kg for a 90kg individual

The recommended daily dose of 300 mg corresponds to the approach used in functional nutrition

Muller AP, Fernandez AM, Haas C, Zimmer E, Portela LV, Torres-Aleman I: Reduced brain insulin-like growth factor I function during aging