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Similar neuroprotective effects have been observed in mouse models of rotenone-induced PD as well, through the inhibition of -synuclein phosphorylation and aggregation, protection of mitochondrial function, inhibition of neuroinflammation, modulation of autophagy, attenuation of oxidative stress and restoration of ER balance (Wang D

Because bile acids facilitate micelle formation required for fat-soluble vitamin absorption, microbial alterations in bile acid pools may indirectly modify vitamin D uptake efficiency

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, MONARCH 1, A Phase II Study of Abemaciclib, a CDK4 and CDK6 Inhibitor, as a Single Agent, in Patients with Refractory HR(+)/HER2() Metastatic Breast Cancer

It discusses the history behind its current association with diverse diseases including neural tube defects, cardio- and cerebrovascular disease and, more recently, dementia and Alzheimers Disease