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The accumulation of senescent cells with age leads to immune reactions that have detrimental effects on the brain

This approach is best suited to: Adults 4065 with longevity-focused health goals who are already engaged in foundational health optimisation (sleep, nutrition, resistance training, metabolic health) Individuals with confirmed age-related decline in GH/IGF-1, with symptoms including reduced lean mass, increased visceral fat, impaired recovery, or sleep-quality deterioration Patients with chronically elevated inflammatory markers without acute disease Adults with disrupted circadian rhythm or age-related sleep degradation (Epitalon specifically addresses this) Those who have optimised foundational lifestyle variables and want an additional, evidence-informed intervention layer It is not appropriate as a standalone intervention for adults who have not addressed metabolic health, sleep, or body composition fundamentals

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Order Clostridiales , family Lachnospiraceae , genus SMB53, and species Ruminococcus gnavus were all more prevalent in the probiotic cow yogurt group (182)

When NADPH electrons are transferred to molecular oxygen during the cellular respiration process, endogenous sources such as NADPH oxidase boost the formation of radical superoxide (Costa et al., 2021)