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Besides PGC-1 inhibition, we also detected changes in fasting glucose and lipid profiles in the mice sera

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While HSC-initiated trained immunity is essential to form long-term memory to launch more robust immune response at young age, this protective mechanism comes at a cost during the aging process when HSCs are exposed to repeated cellular damage and insults

Iurlaro, R

However, concentration, stability, and sterility are variables that matter

Preclinical acute toxicity is low, with reported rodent LD50 values well above any human-equivalent research dose