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However, its clinical translation is hampered by poor bloodbrain barrier penetration (Meade et al., 2020)

The blood supply problem Here is the fundamental challenge

10.1016/S0005-2736(01)00280-2 151 SalzerU.HinterdorferP.HungerU.BorkenC.ProhaskaR

Furthermore, p62 enhances RAS-activated cellular transformation by activating NF-B [131]

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According to the theory of retrograde menstruation, components of refluxed blood, including apoptotic endometrial tissue, desquamated menstrual cells, lysed erythrocytes, and released iron, induce inflammation in the peritoneal cavity
