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The role of cellular reactive oxygen species in cancer chemotherapy

Aerobic exercise Strenuous aerobic or endurance exercise is commonly known to induce ROS and reactive nitrogen species overproduction due to enhanced metabolism, leading to oxidative stress and related injuries (Powers and Jackson, 2008

Front Pharmacol 5:192 Lamoureux GL, Rusness DG (1993) Glutathione in the metabolism and detoxification of xenobiotics in plants

Furthermore, high homocysteine levels can trigger inflammation, endoplasmic reticulum, stress, and other pathways, intensifying mitochondrial damage