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It wasnt until the 1840s, however, that William Beaumont experimentally showed that emotional status affected the rate of digestion and, thus, that the brain affects the gut and that there is a brain-gut axis

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Mood disturbances, such as anxiety, depression, and irritability: These mental health symptoms can indicate a severe deficiency

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Consequently, circumventing blockades, blood flow was restored, and pale areas without mucosal folds did not occur