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Current evidence supports the efficacy of UPA in treating uterine fibroids, but more long-term data is needed to confirm its effects on the endometrium and liver function [176]
This action influences the expression of vascular endothelial growth factor, which controls vasodilation, and inhibits the release of cathelicidin and inflammatory mediators
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Based on these studies, Kim et al
X-ray crystallography has confirmed that the critical arginine residue at position 154 (R154) in its coenzyme A-binding pocket forms a hydrogen bond network with the 3-phosphate group of coenzyme A (Skiba et al., 2020)
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